Bedini, M., Olivetti, E., Avesani, P., & Baldauf, D. (n.d.). Surface-based probabilistic tractography uncovers segregated white matter pathways underlying spatial and non-spatial control.
Bedini (n.d.)
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results
- By contrasting FEF and IFJ connectivity likelihoods, we found predominant structural connectivity from FEF to regions of the dorsal visual stream (particularly in the left hemisphere) compared to the IFJ, and conversely, predominant structural connectivity from the IFJ to regions of the ventral visual stream compared to the FEF.
- tracer evidence suggested that the dorsolateral and ventrolateral PFC were characterized by divergent patterns of anatomical connectivity to the ‘what’ and ‘where’ visual pathways (Goodale & Milner, 1992; Mishkin et al., 1983), respectively (Felleman & Van Essen, 1991; Romanski, 2004; Wilson et al., 1993; Yeterian et al., 2012).
- provided tractography evidence of FEF wiring patterns to the posterior parietal cortex. Baldauf and Desimone (2014) showed that the connectivity likelihood with the fusiform face area and the parahippocampal place area increased in the ventrolateral PFC and near the IFJ.
- SLF1 primarily mediates ‘spatial-motor’, and the SLF3 ‘non-spatial-motor’ functional components (Parlatini et al., 2017).
- The authors found reliable tractography evidence that the human posterior inferotemporal area (phPIT) forms part of an interconnected network encompassing the FEF and the lateral intraparietal area dorsal (LIPd), two well-known areas forming the core of the dorsal attention network.
- the studies briefly reviewed here suggest that the FEF and the IFJ may communicate with posterior parietal and temporal regions through distinct and segregated pathways.
FEF
- the FEF predominantly encodes spatial information (Fiebelkorn & Kastner, 2020; Mackey et al., 2017; Sprague & Serences, 2013; Wang et al., 2015)
- connectivity between the FEF and LIPd is mediated by the SLF2 and in part by the SLF3, and the connectivity between the FEF and phPIT is mediated by the posterior arcuate fasciculus and the inferior fronto-occipital fasciculus
IFJ
- IFJ would predominantly encode non-spatial (i.e., feature- and object-based) information (Baldauf & Desimone, 2014; Bedini & Baldauf, 2021; O’Reilly, 2010)
others
- We speculate that the expansion of the lateral PFC in humans (Donahue et al., 2018) may have led to a greater separation of these domains, which could be one of the factors that allow humans to perform much better in non-spatial tasks and tasks that require greater abstraction abilities compared to the macaque (Levy, 2024).
see also
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Created: 2025-11-19 10:20